In a speech at the party's conference in Bournemouth, he said next June's Euro elections should be a referendum on Britain's relationship with the EU.
And his party would be the "only opposition" voice on the Lisbon Treaty.
"I think we have got to change some of the things that we have been saying and some of the things that we have been doing," argued Mr Farage.
We are the party that says we want to trade with Europe, we want to be friendly with Europe, but we insist that we should make our own laws in this country
In his keynote speech, Mr Farage said: "David Cameron could kill the Lisbon Treaty stone dead.
"All he has to do is say that there will be a referendum on the treaty after the next election when - and let's not kid ourselves on this - he will be prime minister.
"This would strengthen the arms of the Polish and Czech presidents in their refusals to ratify Lisbon and make any
attempt at a second referendum in Ireland impossible."
Mr Farage added: "Everyone knows that the Constitution - sorry, the Lisbon Treaty - will never be approved by the
British people, which is why we've not been asked about it.
The Tories pledged in January to hold a referendum on the Lisbon Treaty if they won power before it was ratified by
all 27 EU states.
But they did not explain whether they would attempt to reopen negotiations on the Treaty if it had been ratified by
every state.
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Published:05/09/2008 © BBC MMVIII